The Pathfinder research to reduce Post- COVID diseases carried out at AIIMS, Patna

Title of the study :
“To study the relationship of  COVID-19 severity with arterial stiffness :  A prospective cross sectional study” (COSEVAST study)
based on PeriScopeTM Arterial Stiffness measurements under treatment Mild, Moderate and Severe COVID-19 patients at AIIMS, Patna.

Article in Times Of India, Patna dated 17th August 2021

COSEVAST study is part of  COVID-19 Global literature on coronavirus disease published by World Health Organization (WHO)

The COSEVAST study outcome: Evidence of COVID-19 severity proportionate to surge in arterial stiffness

Indian Journal of Critical Care Medicine ; 25(SUPPL 1):S108-S111, 2021.

Article in English | EMBASE | ID: covidwho-1200284″

However, since COVID-19 is a highly contagious disease, a fully automatic device with minimal contact, less exposure time, and proximity with the patient need to be maintained. It would be always challenging for an observer to conducting the entire test by wearing full personal protection equipment (PPE) kit. So, a test device that avoids close proximity, long exposure, and holding a probe while testing, was needed for the study. We found that the medical device PeriScope– (Manufactured by M/s. Genesis Medical Systems Pvt. Ltd., Hyderabad, India) was suitable as it fulfilled all the above requirements. PeriScope is a clinically validated and tested noninvasive medical device used to m asure Brachial Ankle PWV (baPWV) and derives the Carotid Femoral PWV (cfPWV), which is equivalent to aortic PWV.”

Abstract of the study obtained from Medrxiv link :


Background: Based on the detailed review of available research and case studies reported in reputed international journals, it can be concluded that endothelial damage (Endotheliitis) both in small and large arteries may be an important factor of morbidity and mortality in COVID-19 patients. Arterial stiffness due to Endothelial Dysfunction has been established as an independent and specific marker of various chronic cardiovascular diseases.

Objective: Our objective was to examine functional impairment of the arteries in COVID-19 disease and establish the non-invasive measurement of Arterial Stiffness as an independent marker of disease severity.

Methods: We recorded the Arterial Stiffness of 23 Mild, 21 Moderate and 20 Severe COVID-19 patients grouped on latest NIH severity criteria. We observed Arterial Stiffness of COVID-19 patients with standard parameters like non-invasive Carotid-Femoral Pulse Wave velocity (cfPWV), Age-Normalized increase in cfPWV (ANI_cfPWV).

Results: Moderate and Severe COVID-19 patients have extremely elevated arterial stiffness than Mild patients. In Mild patients, cfPWV (829.1 ± 139.2 cm/s) was extremely significantly lower than both Moderate (1067 ± 152.5 cm/s, P< 0.0001) and Severe (1416 ± 253.9 cm/s, P < 0.0001) patients. ANI_cfPWV in Moderate and Severe patients was significantly higher than Mild patients. (Mild: 101.2 ± 126.1 cm/s; Moderate: 279 ± 114.4 cm/s; Severe: 580.1 ± 216.4 cm/s; intergroup P <0.0001).

Conclusion: Our findings strongly suggest that arterial stiffness can be an independent and accurate marker for objective risk stratification and therapeutic alleviation of the acute cardiovascular complications like MODS in COVID-19.

Clinical Trial registration

CTRI No.2020/10/028489

“A new study based on the PeriScope device named as ‘Arterial Stiffness based COVID-19 Therapy study (ASCOTH study)’ is underway at AIIMS, Patna and it is showing good results”
-Dr. Neeraj Kumar, AIIMs, Patna

ASCOTH study CTRI Registration number : CTRI/2021/03/032385

For any further queries about the COSEVASTstudy and its outcome, please contact:
Dr. Neeraj Kumar
MBBS (Hons),MD (Anaesthesiology)
Assistant Professor (Trauma & Emergency)
All India Institute of Medical Science(AIIMS),Patna
Bihar India
email : ;